Endocrine Abstracts

Aims: We wanted to evaluate the correlations between the volume of the surgically removed parathyroid adenoma and the presurgical metabolic profile of patients diagnosed with primary hyperparathyroidism.Materials and methods: Prospective multicentric study, enrolling 52 patients with primary hyperparathyroidism from two medical units, proposed for surgery. Serum calcium and PTH were evaluated in all patients before surgery, and 25OH-D3 was measured only ...

Background: PCOS is one of the most common disorders affecting at least 5–10% of women of reproductive age. Increased prevalance of autoimmune thyroiditis and goiter were reported in PCOS patients. This study investigated the prevalance of hypothyroidism, thyroid autoimmunity, ultrasonographic features and presence of nodules in PCOS patients and compare them with the control group. We also aimed to detect correlation of thyroid volume (TV) with serum IGF1 levels in patie...

Objective: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities with insulin resistance (IR) as a major characteristic. It has been recently questioned that MetS and its related components are associated with functional and morphological alterations of thyroid gland. Aim of our study is to examine thyroid volume and nodule prevalence in patients with MetS in a mild-to-moderate iodine deficient area.Design: Two hundred and seventy-eight p...

Insulin resistance (IR) with compensatory hyper-insulinemia are key factors involved in the pathogenesis of glucose metabolism disorders (including impaired fasting glucose and glucose tolerance and frank diabetes mellitus) as well as increased thyroid gland volume and nodule prev-alence in patients with metabolic syndrome. On the other hand, thyroid hormone contributes to the regulation of carbohydrates metabolism and pancreatic function. This cross-sectional study investigat...

Men with spinal cord injury (SCI) exhibit a prostate volume significantly smaller compared to age-matched able-bodied men1–3. As men with chronic SCI (lasting more than 1 year) also display a very high prevalence of androgen deficiency4,5, a protective role of low testosterone against prostate enlargement could be hypothesized in this population. This study aimed to identify independent determinants of prostate volume in men with chronic SCI. As ass...

Introduction: The Syndrome of inappropriate antidiuresis (SIADH) is the predominant cause of hyponatremia and its therapy options are unsatisfying. SGLT2-inhibitors have become a valuable treatment option for type 2 diabetes by increasing glucose excretion in the urine with concomitant osmotic diuresis. We therefore hypothesized that SGLT2-inhibitors could be a novel treatment option for SIADH.Material and methods: We included 14 healthy volunteers in th...

The endocannabinoid system is involved in several homeostatic and neuroendocrine functions. In the present study, we evaluated the effects of type 1 cannabinoid (CB1) receptor antagonist, rimonabant (10 mg/kg, p.o.), on hormone secretion, neuronal activation and mRNA expression in the hypothalamus following isotonic (I−) or hypertonic (H−) blood volume expansion (BVE). Our results showed that the secretion of both oxytocin (OT) and vasopressin (AVP) were increased ...

Both thyroid dysfunction and psychological morbidity are common in the general population. Association between mood disorders and overt thyroid dysfunction are well established. Hypothyroid patients are more prone to depression and anxiety is a frequently reported symptom in thyrotoxicosis. However, the relationship between thyroid hormones in the normal range and psychological well being has not been established.In this study we analysed the relationshi...

Background: Metabolic complications (obesity, lipid abnormalities, and insulin resistance) are prevalent in acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). The hypothalamus (HT) is a complex area involved in endocrine function and metabolic control. In ALL survivors, assessment of the volume of the HT in relation to metabolic parameters including ghrelin, a peptide stimulating food intake, has not been performed previously.<p class="ab...

The aim of this study was to determine the relationship between biochemical parameters, parathyroid adenoma volume, and bone mineral density with respect to intact parathyroid hormone (iPTH) levels in patients with primary hyperparathyroidism. Data were collected retrospectively from patients with primary hyperparathyroidism who were diagnosed and followed-up at our clinic between 2004 and 2008. Forty-eight (female/male=42/6) patients with a mean age of 52.8±13.1 (range 2...